Centralization: a new method for the normalization of gene expression data
نویسندگان
چکیده
منابع مشابه
Centralization: a new method for the normalization of gene expression data
Microarrays measure values that are approximately proportional to the numbers of copies of different mRNA molecules in samples. Due to technical difficulties, the constant of proportionality between the measured intensities and the numbers of mRNA copies per cell is unknown and may vary for different arrays. Usually, the data are normalized (i.e., array-wise multiplied by appropriate factors) i...
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Advances in microarray technologies have made it possible to comprehensively measure gene expression profiles. However, in these experiments, the efficiency of fluorescent dyes are different between different experiments, and adjustments of these expression values are mandatory before the analysis, It is referred to as normalization. Although the most popular method is total intensity normaliza...
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هدف اصلی از این تحقیق به دست آوردن و مقایسه حق بیمه باورمندی در مدل های شمارشی گزارش نشده برای داده های طولی می باشد. در این تحقیق حق بیمه های پبش گویی بر اساس توابع ضرر مربع خطا و نمایی محاسبه شده و با هم مقایسه می شود. تمایل به گرفتن پاداش و جایزه یکی از دلایل مهم برای گزارش ندادن تصادفات می باشد و افراد برای استفاده از تخفیف اغلب از گزارش تصادفات با هزینه پائین خودداری می کنند، در این تحقیق ...
15 صفحه اولMathematical Supplement to Centralization: a New Method for the Normalization of Gene Expression Data 1 Estimation of Most Consistent Sample Scaling Factors
Core to the Centralization method 1] for the normalization of gene expression data is the estimation of most consistent sample scaling factors based on possibly inconsistent pairwise estimates. Here, the maximum likelihood approach that is employed in order to nd the most probable consistent scaling vector is described in detail. Let i; j 2 A be two microarray measurements of any two samples wi...
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MOTIVATION Genomic instability is one of the fundamental factors in tumorigenesis and tumor progression. Many studies have shown that copy-number abnormalities at the DNA level are important in the pathogenesis of cancer. Array comparative genomic hybridization (aCGH), developed based on expression microarray technology, can reveal the chromosomal aberrations in segmental copies at a high resol...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2001
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/17.suppl_1.s323